With the NFL in full swing, so are the headlining stories. In their new weekly segment, Marcellus Wiley and Emmanuel Acho share what to watch in Week 1, including the most intriguing matchup. Hear what Wiley and Acho have to say about the Indianapolis Colts - Seattle Seahawks and Pittsburgh Steelers - Buffalo Bills matchups. The duo also shares the quarterbacks they have their eyes on, including Matthew Stafford's debut with the Los Angeles Rams and Justin Herbert's first game in front of a crowd in Washington. Finally, Wiley & Acho share the players who have the most to prove, Jameis Winston superseding Drew Brees, and whether Ben Roethlisberger can bounce back from a down year.